Molybdenum-cofactor-containing enzymes: structure and mechanism.

Molybdenum Cofactor Biology and Disorders Related to Its Deficiency; A Review Study

Background: Molybden, as a vital and essential micronutrient is directly involved in the metabolism of other elements including carbon, sulfur, and nitrogen. Molybdenum alone is not biologically active unless it binds to specific cofactors. Except for the bacterial nitrogenase, which contains molybdenum-Iron complex, molybdenum cofactor (Moco) is considered as the bioactive component placed in ...

A crystallographic view of the molybdenum cofactor †

The molybdenum cofactor (Moco) has been found to be associated with a diverse set of redox enzymes and contains a mononuclear molybdenum or tungsten ion co-ordinated by the dithiolene sulfurs of one or two molybdopterin {a pterin [2-amino-4(1H )-pteridinone] derivative} ligands. The remaining co-ordination sites on the metal are occupied by non-protein oxygen or sulfur species and, occasionally...

A structural comparison of molybdenum cofactor-containing enzymes.

This work gives an overview of the recent achievements which have contributed to the understanding of the structure and function of molybdenum and tungsten enzymes. Known structures of molybdo-pterin cofactor-containing enzymes will be described briefly and the structural differences between representatives of the same and different families will be analyzed. This comparison will show that the ...

Tungsten-acetylene hydratase from Pelobacter acetylenicus and molybdenum-transhydroxylase from Pelobacter acidigallici: Two novel molybdopterin and iron-sulfur containing enzymes

Characterization of the Molybdenum Cofactor of Sulfite Oxidase, Xanthine Oxidase, and Nitrate Reductase

While the existence of a molybdenum cofactor common to nitrate reductase, xanthine oxidase, and sulfite oxidase has been finnly established by studies from several laboratories (1-6), the nature of the molecule has not been elucidated. Information available to date has shown that the molybdenum cofactor complex is noncovalently attached to the proteins (2, 4) and is probably a small, dialyzable...